LAURA H. CYPHERS

This Medical News article examines the American Cancer Society’s projected case and mortality rates for cancer this year in the US.
Source: JAMA Online First

The Original Investigation titled “Effect of intravenous tenecteplase dose on cerebral reperfusion before thrombectomy in patients with large vessel occlusion ischemic stroke: the EXTEND-IA TNK Part 2 randomized clinical trial” that was published February 20, 2020, has been corrected to include the nonauthor collaborator names in a supplement.
Source: JAMA Online First

This Viewpoint discusses the recent FDA approval of cabotegravir, the first injectable medication to help prevent HIV infection, and how its effectiveness may be complicated by the cost and complexity of the US health care system.
Source: JAMA Online First

This study estimates the associations between symptomatic SARS-CoV-2 infection and receipt of BNT162b2, mRNA-1273, and Ad26.COV2.S by day since vaccination before and during Delta variant predominance.
Source: JAMA Online First

This study estimates SARS-CoV-2 infections and disease severity with the receipt of a booster and by type of booster.
Source: JAMA Online First

This Viewpoint argues that evidence shows that transient ischemic attacks are neither benign nor transient and should be retired as a neurological diagnostic term in favor of acute ischemic cerebrovascular syndrome.
Source: JAMA Online First

This retrospective cohort study uses data from hospitals participating in the Get With The Guidelines–Stroke registry on patients with acute ischemic stroke and compares the safety and functional outcomes of intravenous alteplase among patients who were taking non–vitamin K antagonist oral anticoagulants (NOACs) prior to stroke vs patients who were not taking long-term anticoagulants.
Source: JAMA Online First

This randomized clinical trial assesses the effect of intra-arterial alteplase infusion vs placebo on functional outcomes (modified Rankin Scale scores) among patients with large vessel occlusion acute ischemic stroke and successful reperfusion following thrombectomy.
Source: JAMA Online First

This Viewpoint describes a report from the National Academies of Sciences, Engineering, and Medicine that proposes a framework for respiratory protection for individuals not provided with work-related equipment, including members of the public.
Source: JAMA Online First

Acute ischemic stroke remains a leading cause of disability in the United States and worldwide despite substantially improved treatments for the most severe strokes over the last 5 years. Treatment of severe ischemic strokes, specifically those due to occlusion of large intracranial arteries, has been transformed by endovascular removal of the thrombus using stent retrievers or aspiration catheters. Treatment with mechanical thrombectomy is associated with a 20% to 27% absolute increase in the rate of functional independence compared with patients not treated with thrombectomy. Despite highly efficacious treatment, approximately 54% of patients who experience severe strokes have functional dependence or die, and among those who survive, approximately 72% have some degree of disability.
Source: JAMA Online First