This Medical News feature describes how the Russian invasion has disrupted clinical trials in Ukraine as well as Russia.
Source: JAMA Online First
| Curriculum Vitae | Résumé |
This Medical News feature describes how the Russian invasion has disrupted clinical trials in Ukraine as well as Russia.
Source: JAMA Online First
This Medical News article summarizes a recent Clinical Reviews interview with Dr Andres M. Kanner, MD, of the University of Miami Miller School of Medicine in Miami, Florida about the management of epilepsy in adults using antiseizure drugs.
Source: JAMA Online First
This randomized clinical trial compares the efficacy and adverse effects of the 3 most frequently prescribed corticosteroid regimens for boys with Duchenne muscular dystrophy.
Source: JAMA Online First
Heart failure is a complex clinical syndrome associated with frequently debilitating and lethal outcomes. Continual advancement in understanding the varied etiologies and specific molecular and mechanical processes underlying heart failure have led to lifesaving advances in the management of this disorder; however, the annual morbidity, mortality, and economic costs related to heart failure remain unacceptably high. Improved care options, including the precise targeting of specific physiological derangements that underlie heart failure pathology, offer hope for an improved outlook for patients.
Source: JAMA Online First
This retrospective population-based cohort study compares carriers of the amyloidogenic Val122Ile TTR variant vs noncarriers to assess the association of having the variant with risk of heart failure and mortality in self-identified Black individuals living in the US.
Source: JAMA Online First
Lipoprotein(a) (Lp[a]) is a cholesterol-carrying, apolipoprotein B (apo B)–containing lipoprotein that has an apolipoprotein(a) (apo[a]) moiety covalently attached to its apo B100 molecule. The attached apo(a) moiety interferes with the interaction between Lp(a) and the apo B100–dependent low-density lipoprotein receptor, resulting in a long circulating half-life and accumulation of oxidized phospholipids within Lp(a).
Source: JAMA Online First
This randomized clinical trial examines the effect of early administration of the PCSK9 inhibitor alirocumab on coronary atherosclerosis using serial multimodality intracoronary imaging in patients with acute myocardial infarction.
Source: JAMA Online First
This phase 1 study evaluated the safety and tolerability of 4 different doses of a short interfering RNA designed to reduce hepatic production of apolipoprotein(a) and assessed associated changes in plasma concentrations of lipoprotein(a), compared with placebo, among individuals with elevated lipoprotein(a) levels and no known cardiovascular disease.
Source: JAMA Online First
This Viewpoint from Gostin and Rubenstein examine the violence against health care workers and institutions in the war in Ukraine and potential paths to hold those perpetuating such attacks accountable.
Source: JAMA Online First
This study evaluates the association between SARS-CoV-2 load in urban wastewater and surveillance indicators of infection prevalence and severity in Milan, Italy.
Source: JAMA Online First