A woman developed pruritic wheals on her face and bilateral, transient eyelid swelling 12 days after receiving a COVID-19 mRNA booster vaccine (Moderna). During examination, wheal and flare lesions developed on her upper eyelids and resolved after 30 minutes; light pressure applied to her skin with a tongue depressor elicited wheal and flare lesions within 3 to 5 minutes. What is the diagnosis and what would you do next?
Source: JAMA Online First

This Viewpoint discusses increases in opioid use disorder among pregnant people during the US opioid crisis and recommendations to define, diagnose, and treat neonatal abstinence syndrome and neonatal opioid withdrawal syndrome.
Source: JAMA Online First

In this narrative medicine essay, a movement disorders neurologist, whose examinations rely on gauging facial expressions, contemplates the complexities of day-to-day lost connectivity while wearing masks during the COVID-19 pandemic and savors now the renewed intimacies experienced face to face.
Source: JAMA Online First

This Medical News article discusses insomnia in children.
Source: JAMA Online First

In the Medical News & Perspectives article “Medical Groups Defend Patient-Physician Relationship and Access to Adolescent Gender-Affirming Care,” published online March 30, 2022, in JAMA, Dr Turban was incorrectly identified as having served as an expert witness in a Texas case. This article was corrected online.
Source: JAMA Online First

This Viewpoint discusses approaches to improving diagnostic excellence, including realignment of economic incentives, development of metrics, and reporting performance.
Source: JAMA Online First

This Viewpoint describes pricing with evidence development whereby the price of a drug evolves in accordance with the evidence of its clinical benefit.
Source: JAMA Online First

Prolonged invasive mechanical ventilation is associated with considerable morbidity among critically ill children, including secondary infections, exposure to potentially neurotoxic sedatives, and muscle wasting. These adverse outcomes may have detrimental effects on childhood development. Children who require invasive mechanical ventilation also pose a unique set of clinical challenges. Short airways require precise endotracheal tube position, lower functional residual capacities potentiate the likelihood of hypoxemia, and episodes of inconsolability may lead to sedation administration. Such factors can impede implementation of intensive care unit liberation bundles, including those designed to promote wakefulness, spontaneous breathing, and ambulation.
Source: JAMA Online First

This clinical trial evaluates the noninferiority of high-flow nasal cannula (HFNC) therapy vs continuous positive airway pressure (CPAP) as the first-line mode of noninvasive respiratory support following extubation on time to liberation from respiratory support.
Source: JAMA Online First

This Medical News feature discusses supervised consumption sites for people who use illicit drugs.
Source: JAMA Online First