LAURA H. CYPHERS

Overall, youth who received gender-affirming hormones (GAH) for 2 years improved on several measures of well-being, according to the findings of a prospective observational study published in the New England Journal of Medicine. The study involved 315 transgender and nonbinary participants aged 12 years to 20 years who received testosterone or estradiol at 4 urban pediatric gender centers in the US.
Source: JAMA Online First

This Medical News story discusses a study that found possible associations between postural orthostatic tachycardia syndrome (POTS) and COVID-19 vaccination and SARS-CoV-2 infection.
Source: JAMA Online First

This Medical News article discusses the total collapse of health care systems in Ethiopia during a 2-year armed conflict.
Source: JAMA Online First

This JAMA Guide to Statistics and Methods article examines conditional power, calculated while a trial is ongoing and based on both the currently observed data and an assumed treatment effect for future patients.
Source: JAMA Online First

This Arts and Medicine feature reviews the 2019 movie Collective, which documents corruption underlying poor patient outcomes in the Romanian national health system and provides an update on the people and reform efforts featured in the film.
Source: JAMA Online First

This Viewpoint discusses the failure of the Centers for Medicare & Medicaid Services’ SEP-1 sepsis outcome improvement initiative to improve patients’ sepsis outcomes and suggests changing the focus of sepsis quality metrics from processes to outcomes.
Source: JAMA Online First

This JAMA Insights Clinical Update examines treatment recommendations and therapy options among adults with latent tuberculosis infection.
Source: JAMA Online First

This Viewpoint reviews California’s recently proposed CalRx initiative to manufacture biosimilar insulin, highlights challenges facing the initiative, and suggests ways in which, if successful, the initiative could serve as a model for state-managed development of drugs other than insulin, reduce drug prices, and provide other benefits.
Source: JAMA Online First

Letters reminding clinicians of a mandate to check a state prescription tracking database before prescribing opioids significantly increased clinician participation in the program. The approach may promote better-informed and potentially safer opioid prescribing, according to a study in Health Affairs.
Source: JAMA Online First

Patients who were diagnosed with mild COVID-19 were up to 4.6 times more likely than uninfected patients to have some symptoms associated with post–COVID-19 condition (PCC) for 6 to 12 months, according to a study in The BMJ.
Source: JAMA Online First