This Viewpoint discusses the goals of the inaugural National Drug Control Strategy, which as the ambitious agenda of emphasizing harm reduction practices, medications for treating opioid use disorder, and criminal justice reform, as well as supporting long-term recovery and interrupting illicit drug trafficking.
Source: JAMA Online First

This observational study explores whether rubella serostatus, which is routinely assessed during pregnancy, can serve as a proxy for measles serostatus in parturient persons.
Source: JAMA Online First

This study examines the appropriateness of artificial intelligence model responses to fundamental cardiovascular disease prevention questions.
Source: JAMA Online First

A man in his 60s had irregular gray-white ulcers with a surrounding erythema on the soft palate, uvula, and tonsils that did not improve with oral cefuroxime. He reported sexual contact with 1 male partner over the prior 6 months; history and physical examination findings were otherwise unremarkable. What is the diagnosis and what would you do next?
Source: JAMA Online First

This JAMA Patient Page describes the autoimmune disease Guillain-Barré syndrome and its risk factors, diagnosis, treatment, and prognosis.
Source: JAMA Online First

An estimated 491 000 fewer people than expected began antihypertensive medications in the UK between March 2020 and July 2021 during the COVID-19 pandemic. The decline, reported in Nature Medicine, could result in more than 13 000 additional cardiovascular disease events, including nearly 2300 myocardial infarctions and 3500 strokes, should these patients remain untreated over their lifetimes, the authors predicted.
Source: JAMA Online First

The discovery of a molecular factor that helps many types of coronaviruses invade host cells could lead to COVID-19 treatments that retain effectiveness as SAR-CoV-2 mutates, according to a study in Proceedings of the National Academy of Sciences.
Source: JAMA Online First

Patients with sepsis-induced hypotension resuscitated in the first 24 hours with lower volumes of intravenous fluid and greater vasopressor use were about as likely to survive as patients treated with higher intravenous fluid volumes prioritized over vasopressors. The trial results, reported in the New England Journal of Medicine, contradicted the initial hypothesis that a restricted fluid strategy would reduce mortality.
Source: JAMA Online First

This Medical News article discusses a new study of household food purchasing trends from 2008 to 2020.
Source: JAMA Online First

This Medical News article discusses a clinical trial for an HIV vaccine that uses germline targeting, a novel technique to induce rare immune cell precursors of broadly neutralizing antibodies.
Source: JAMA Online First