LAURA H. CYPHERS

This Medical News feature discusses the ongoing research into intranasal COVID-19 vaccines.
Source: JAMA Online First

This study uses data from a nationally representative longitudinal study of adults in the US to examine individual-level change in vaccine intent and uptake between April and July 2021.
Source: JAMA Online First

This Viewpoint summarizes new guidance from the US Food and Drug Administration (FDA) for industry to voluntarily adhere to sodium reduction targets, particularly in processed and prepared foods.
Source: JAMA Online First

COVID-19, the infectious disease caused by the SARS-CoV-2 virus, has been associated with an inflammatory and hypercoagulable state characterized by increases in levels of D-dimers, fibrin, fibrin degradation products, and fibrinogen. Observational studies suggest that elevations in levels of these markers translate into increased rates of mortality and thromboembolic events. These findings motivated the design and conduct of several randomized clinical trials aimed at evaluating the efficacy and safety of different antithrombotic regimens in patients with COVID-19.
Source: JAMA Online First

This study investigates the temporal trend in racial and ethnic differences in use of intravenous thrombolysis for stroke treatment between 2009 and 2018 in a representative sample of US adults.
Source: JAMA Online First

This randomized clinical trial assesses whether aspirin, prophylactic-dose apixaban, or therapeutic-dose apixaban, compared with placebo, can safely reduce major adverse cardiopulmonary outcomes among symptomatic but clinically stable US outpatients with COVID-19.
Source: JAMA Online First

This Viewpoint describes the Center for Medicare and Medicaid Innovation’s proposed project called Pay for Drugs That Work, which would aim to restrain high prices for drugs that receive accelerated approval from the US Food and Drug Administration.
Source: JAMA Online First

This Viewpoint posits that advance care planning does not achieve the stated goal of end-of-life care nor serve as a reliable indicator of an end-of-life discussion.
Source: JAMA Online First

This Viewpoint explores several spiritual considerations that may support clinicians in their work and also presents resources that may help clinicians in their professional and personal lives not only during the pandemic but also throughout their careers.
Source: JAMA Online First

Based on the Vaccine Adverse Event Reporting System, this article reports on the prevalence of presumptive Guillain-Barré syndrome among recipients of the Ad26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccine.
Source: JAMA Online First