This multicenter randomized clinical trial assesses the effect of use of a tracheal tube introducer vs an endotracheal tube with stylet on successful intubation on the first attempt among critically ill adults undergoing tracheal intubation in emergency departments and intensive care units between 2019 and 2021.
Source: JAMA Online First

This Medical News article on the newest SARS-CoV-2 variant of concern is adapted from a JAMA video interview recorded on December 1, 2021.
Source: JAMA Online First

This Viewpoint discusses the recent FDA-proposed draft guidance on benefit-risk assessment to guide its review of new drug and biological products and how this approach will enhance its mission to protect public health.
Source: JAMA Online First

Late last year, UK health authorities announced that the second dose of authorized COVID-19 vaccines would be administered up to 12 weeks instead of 3 to 4 weeks after the first dose. The change was intended to free up initial doses for more people, but it also created an opportunity to investigate a vaccine schedule that hadn’t been tested in clinical trials.
Source: JAMA Online First

This study investigates the immunogenicity of extended mRNA vaccine dosing intervals.
Source: JAMA Online First

This study assesses state-level legal interventions to promote or impede COVID-19 vaccine mandates in the US since the beginning of the pandemic.
Source: JAMA Online First

This Viewpoint argues for a change in the assessment of patient experience in health care, moving from norm-based scores and rankings to a criterion-based system with transparent reporting of results.
Source: JAMA Online First

This Medical News article is an interview with physician-geneticist Francis S. Collins, MD, PhD, as he ends his historic tenure as director of the National Institutes of Health.
Source: JAMA Online First

This placebo-controlled randomized clinical trial compares administration of calcium vs saline during out-of-hospital cardiac arrest for sustained return of spontaneous circulation in adults.
Source: JAMA Online First

This Arts and Medicine feature surveys the life and scholarship of James McCune Smith, MD, a 19th-century New York physician who cared for poor individuals, debunked pseudoscience justifying racism, and published broadly in medicine and public health.
Source: JAMA Online First