Intravenous thrombolytic therapy with recombinant tissue plasminogen activator (alteplase) is the cornerstone of acute ischemic stroke reperfusion therapy and is associated with significant improvements in outcomes. Historically, a number of exclusion criteria for use of alteplase had been in place, but over the past 20 years, some of these have been eliminated (eg, age >80 years, seizures at stroke onset) or have become less stringent (eg, exclusion criteria may not strictly apply to recent vitamin K antagonist treatment if the patient has an international normalized ratio <1.7, and treatment may be administered in an extended time window in some patients).
Source: JAMA Online First
This Medical News feature examines the impact of pandemic-related social isolation on individuals with Parkinson disease.
Source: JAMA Online First
This study compared the persistence anti-Spike IgG titers in infants of vaccinated mothers vs mothers who had been naturally infected with COVID-19.
Source: JAMA Online First
This Viewpoint summarizes safety assessment guidelines developed by the Centers for Medicare & Medicaid Services to improve patients’ safety by optimizing clinicians’ use of electronic health record systems.
Source: JAMA Online First
This cohort study evaluates the association of SARS-CoV-2 infection with serious maternal morbidity or mortality related to hypertensive disorders of pregnancy, postpartum hemorrhage, or infection other than SARS-CoV-2.
Source: JAMA Online First
This study assesses how a limited supply of monoclonal antibody therapy was allocated to patients at highest risk of severe disease among a population of fee-for-service Medicare beneficiaries with a new COVID-19 diagnosis or confirmed exposure between November 2020 and August 2021.
Source: JAMA Online First
This Viewpoint discusses a new federal rule (part of the 21st Century Cures Act) that mandates US clinicians and health organizations make electronic health records more accessible to patients, examines the potential legal benefits and risks of sharing clinical notes, and offers recommendations for ensuring that the new rule advances the interests of both patients and clinicians.
Source: JAMA Online First
This study examines SARS-CoV-2 infections detected in close contacts of confirmed cases within the Olympic Village at the 2021 Tokyo Olympic and Paralympic Games.
Source: JAMA Online First
This study uses serologic testing to characterize natural immunity and the long-term durability of SARS-CoV-2 antibodies among unvaccinated US adults by history of COVID-19 infection.
Source: JAMA Online First
Patients who are hospitalized with COVID-19 have elevated rates of postdischarge thrombotic events, but uncertainty exists about whether thromboprophylaxis should continue beyond the hospital stay. In a recent phase 3 trial, continuing thromboprophylaxis after patients hospitalized with COVID-19 were discharged reduced major and fatal thromboembolic events without increasing major bleeding.
Source: JAMA Online First